{"created":"2023-06-19T09:47:25.677472+00:00","id":1932,"links":{},"metadata":{"_buckets":{"deposit":"5b5da751-503a-4df1-b5ec-d1826fc085dc"},"_deposit":{"created_by":3,"id":"1932","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1932"},"status":"published"},"_oai":{"id":"oai:shukutoku.repo.nii.ac.jp:00001932","sets":["205:225"]},"author_link":["3773","3776","3774","3772","3771","3769","3770","3775"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-16","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"淑徳大学看護栄養学部紀要"},{"bibliographic_title":"Journal of the School of Nursing and Nutrition Shukutoku University","bibliographic_titleLang":"en"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"【目的】葉酸摂取不足や葉酸代謝関連酵素の遺伝子多型MTHFR C677Tは高ホモシステイン（Hcy）血症を招き、動脈硬化性疾患のリスクを高める。そこで20～60歳代の勤労男性を対象に、遺伝子多型に基づくテーラーメイド栄養指導を行い、血清葉酸、Hcy濃度の変化と介入回数、期間の反映を検討した。\n【方法】対象は20～60歳代の自治体職員研修会参加者の男性で、血清葉酸およびHcy濃度、葉酸や緑黄色野菜摂取量と遺伝子多型に基づき、葉酸摂取を中心とした栄養指導を行った。Ａ群（n=43）では初回介入の３か月後とその約１年後に介入し、Ｂ群（n=69）では初回介入の約１年後に介入して、葉酸栄養状態の指標を測定して比較した。\n【結果】Ａ群では血清葉酸濃度、血清Hcy濃度に有意な改善がみられ、TT型での変化量が他の多型より有意に大きくなった。Ｂ群の初回の葉酸、Hcy濃度は多型間差がなく、介入後有意な変化はみられなかった。葉酸や野菜摂取量は両群とも有意な増加はみられなかった。\n【結論】勤労男性への遺伝子多型基づく栄養指導は、多型間差がある場合、葉酸栄養状態改善に効果があることが確認された。複数回の介入が改善状態の継続に有効である可能性が示された。","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Folate deficiency and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms lead to elevated blood homocysteine (Hcy) levels and increase the risk of arteriosclerosis. In this study, we investigated the effects of personalized nutrition guidance based on genetic polymorphisms and duration and frequency of interventions on serum folate and Hcy concentrations in working men. The subjects were men in their 20s and 60s who participated in a local government workshop. Based on serum folate and Hcy concentrations, green-yellow vegetable intake, and genetic polymorphisms, nutritional guidance was provided to increase folate intake. In group A (n = 43), intervention was performed 3 months after the initial intervention and about 1 year thereafter. In group B (n = 69), intervention was performed about 1 year after the initial intervention. Indicators of folate nutritional status were compared between the two groups. The serum folate concentration and the serum Hcy concentration were significantly improved in Group A. Changes in serum Hcy concentration were significantly greater in the TT genotype than in other polymorphisms. Neither serum folate concentration nor serum Hcy concentration was significantly changed in Group B.\nIn conclusion, genotype-based nutritional guidance was effective in improving folate nutritional status in male workers when there are differences between polymorphisms. It was also shown that the multiple interventions may be effective in maintaining a state of improvement.","subitem_description_type":"Other"}]},"item_2_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"2","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12608931","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21876789","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"淑徳大学看護栄養学部"},{"subitem_text_value":"女子栄養大学"},{"subitem_text_value":"ヤクルト本社"},{"subitem_text_value":"女子栄養大学"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"キンロウ ダンセイ ニオケル イデンシ タケイベツ テーラー メイド エイヨウ シドウ ニヨル ケッセイ ヨウサン､ホモシステイン ノウド ニタイスル エイキョウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平岡, 真実"},{"creatorName":"ヒラオカ, マミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂本, 香織"},{"creatorName":"サカモト, カオリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"百合本, 真弓"},{"creatorName":"ユリモト, マユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"香川, 靖雄"},{"creatorName":"カガワ, ヤスオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiraoka, Mami","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yurimoto, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kagawa, Yasuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-02"}],"displaytype":"detail","filename":"kangoeiyogakubukiyo_013_001_011.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kangoeiyogakubukiyo_013_001_011.pdf","url":"https://shukutoku.repo.nii.ac.jp/record/1932/files/kangoeiyogakubukiyo_013_001_011.pdf"},"version_id":"40f2e823-b5bb-4674-8086-57135d4d0faa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"葉酸","subitem_subject_scheme":"Other"},{"subitem_subject":"ホモシステイン","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子多型","subitem_subject_scheme":"Other"},{"subitem_subject":"メチレンテトラヒドロ葉酸還元酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"テーラーメイド栄養","subitem_subject_scheme":"Other"},{"subitem_subject":"folate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"homocysteine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"genotype","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MTHFR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"personalized nutrition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"勤労男性における遺伝子多型別テーラーメイド栄養指導による血清葉酸、ホモシステイン濃度に対する影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"勤労男性における遺伝子多型別テーラーメイド栄養指導による血清葉酸、ホモシステイン濃度に対する影響"},{"subitem_title":"Effect of genotype-based personalized nutrition guidance on serum folate and homocysteine concentrations in male workers","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["225"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-02"},"publish_date":"2021-03-02","publish_status":"0","recid":"1932","relation_version_is_last":true,"title":["勤労男性における遺伝子多型別テーラーメイド栄養指導による血清葉酸、ホモシステイン濃度に対する影響"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T09:58:29.737869+00:00"}